The simple answer is that no, we do not support any sign making software. That doesn't mean they won't work, but you will need to contact the maker of your sign software to see if it supports Adobe Photoshop plug-ins in 32 or 64-bit.
Current Alien Skin Software is 64-bit only. Versions compatible with 32-bit host programs are available here.
You will likely need this custom install article. It will help you install it where the software vender tells you to.